From Scientific Exile To Gene Editing Pioneer

Recombinant DNA technology allows scientists to cut, edit and clone individual genes.

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Gene editing was a new idea in the mid-1970s. So when two of America's most prestigious research institutions planned a new facility for work in recombinant DNA, the technology that lets scientists cut and reassemble genes, alarm bells went off.

"The way they would put it was, we're mucking around with life," says Lydia Villa-Komaroff, then a freshly minted MIT PhD in cell biology. "People were worried about a 'Frankengene,' that perhaps by moving a piece of DNA from one organism to another, we might cause something that was truly dreadful."

Amidst a political circus, the city of Cambridge, Massachusetts banned research into recombinant DNA within city limits, specifically at MIT and Harvard. That forced scientists like Villa-Komaroff into exile. She spent months at Cold Springs Harbor Laboratory, plugging away on experiments that didn't work.

But that turned out to be just the prelude to a triumph, a breakthrough in recombinant DNA technology that directly benefits millions of Americans today. In this episode, Dr. Villa-Komaroff tells Emily Kwong the story of overcoming the skeptics during the dawn times of biotechnology, and how she helped coax bacteria into producing insulin for humans.

Publication: Barbara J. Culliton, et al., Recombinant DNA: Cambridge City Council votes moratorium, Science (2022). DOI: 10.1126/science.1164332

Original Story Source: Massachusetts Institute of Technology