Researchers introduced Introme, a machine-learning tool that integrates multiple-splice prediction tools, additional splicing rules, and gene architecture features to evaluate the likelihood of a variant impacting splicing. The study was done by Patricia Sullivan, Velimir Gayevskiy, and several others and published by BioMed Central (BMC).
A study using an ingestible sampling device uncovered significant metabolome differences in the upper intestinal tract during routine daily digestion, highlighting the complex interplay between diet, host, and microbial metabolism. The study by Dr. Jacob Folz, Dr. Rebecca Culver, and many others was published on May 10 in Nature Metabolism.
Researchers investigated how the gut microbiome and metabolic indicators in individuals with pre-diabetes are affected by different diets. The study by Orly Ben-Yacov, Anastasia Godneva, Michal Rein, and several others was published online on July 6.
Researchers studied the accumulation of somatic mutations, due to genome repair and replication errors, their role in aging, and strategies to manage these mutations. The study was published on April 28 and was authored by Jan Vijg, Björn Schumacher, Abdulkadir Abakir, and several others.
A recent study explores the influence of mild mitonuclear incompatibilities on Drosophila's response to N-acetyl cysteine (NAC)-induced redox stress. The report from May 2023 highlighted how NAC's impact varies with factors such as mitonuclear genotype, gender, and tissue, demonstrating that complex I-linked respiration suppression is a crucial factor in mitigating redox stress, occasionally resulting in mortality.
A recent study shows that after achieving remission in pediatric Crohn’s disease using exclusive enteral nutrition, the use of autologous fecal microbiota transfer capsules showed potential, but challenges like high pathogens and inconsistent stool quality raised concerns about its viability as a long-term treatment. The study by Hannes Hoelz, Jeannine Heetmeyer, Anastasia Tsakmaklis, and many others was published on April 2, 2023.
Burkholderia cepacia complex (Bcc) infections are a serious concern for cystic fibrosis (CF) patients, often leading to the need for lung transplants. On March 16, researchers from Texas A&M developed a versatile phage called Milagro vir gp20:Milo Δcl from Milagro to combat multiple drug-resistant Bcc species, and they've also created a CRISPR/Cas9 system for direct gene editing of virulent phages.
The use of protein biomarker panels, as opposed to individual markers, has the potential to improve precision medicine by providing a more comprehensive understanding of human physiology, according to an EMBO Press research report from March 20. Nonetheless, the integration of proteomics into clinical practice encounters obstacles, with targeted mass spectrometric assays emerging as a promising solution due to their adaptability and cost-effectiveness.
A team of scientists in Montreal and Paris has succeeded in identifying the gene responsible for the development of a food-dependent form of Cushing’s Syndrome,
Researchers at Yale University recently analyzed more than 300 kinases in the human body that showed insights into what proteins the enzymes are most likely to target, which leads to a better understanding of human biology and treating diseases. According to a release on February 14 from Yale, the findings show how kinases recognize targets based on amino acid sequences, which provides a valuable online resource for other researchers.
UC San Diego researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial
In a nationwide, multi-center clinical trial, researchers identified a potential new drug that improved liver fibrosis in patients with NASH by 27%
The Pfizer BioNTech vaccine BNT162b2 is likely to be effective against the B1.1.7 variant of SARS-CoV-2, even though its efficacy is modestly affected, say scientists at the University of Cambridge.
Irwin and Joan Jacobs’ philanthropy establishes endowed chair and research fund for largely unexplored area of patient health
New research has found that changes in body fat impact early markers of heart health more than changes in body muscle, suggesting there are greater benefits to be expected from losing fat than from gaining muscle.
The SARS-CoV-2 epidemic has already had a major impact on children's education, with schools having been required to implement infection control measures that have led to long periods of absence and classroom closures.
An expert review by an international group of scientists, including the World Health Organisation (WHO), Food and Drug Administration (FDA) and the University of Bristol,
Efforts to discourage people from smoking by banning tobacco retail displays in shops and supermarkets could be weakened by prominent displays of electronic (e) cigarettes and smoking paraphernalia,