Czech Anticancer Agent Works on Type 2 Diabetes

A team of scientists and physicians from the Institute of Biotechnology of the CAS at the BIOCEV centre and the Institute of Clinical and Experimental Medicine in Prague has demonstrated a positive effect of MitoTam on type 2 diabetes. The research was published today in the prestigious journal Nature Communications.

Type 2 diabetes (D2T) was induced in mouse models by a six-month high-fat diet. "After treatment with MitoTam, body weight dropped almost to the level of mice on the control diet. There was also a reduction in blood glucose and insulin production, indicating suppression of insulin resistance," says Prof. Jiří Neužil, Head of the Laboratory of Molecular Therapy (Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre). "The substance has also shown an extraordinary effect on the liver, which loses its function during diabetes due to fat deposition and undergoes gradual cirrhosis," adds Prof. Neužil.

Publication: Eliska Vacurova, et al., Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice, Nature Communication (2023). DOI: 10.1038/s41467-022-29486-z

Original Story Source: Czech Academy of Sciences