A new publication from the Hickson group at the CCS in Molecular Cell

On the 23rd Aug., the Hickson group published a paper that defines the role of RAD51 (and its partner, BRCA2), in preventing the damaging effects of transcription-replication conflicts in S-phase in human cells.

This role for RAD51 suppresses DNA fork breakage and the subsequent amplification of genomic regions that are commonly observed in cancer cells.

Publication: Rahul Bhowmick, et al., RAD51 protects human cells from transcription-replication conflicts, National Library of Medicine (2023). DOI:10.1016/j.molcel.2022.07.010

Original Story Source: University of Copenhagen