Bacteria Control Their Metabolism When Going into Biofilm Formation

In a new paper out now in  Cell Reports, a research team from Costerton Biofilm Center at the Department of Immunology and Microbiology (ISIM), University of Copenhagen - with Assistant professor Mads Lichtenberg, Assistant professor Kasper Nørskov Kragh, Professor Tim Tolker-Nielsen and Professor Thomas Bjarnsholt in front - describes how in response to cyclic-di-GMP, bacterial populations exhibit a burst of metabolic activity followed by a prolonged period of low metabolic activity as they enter the biofilm state.

This fundamental research using biocalorimetry helps us to better understand biofilm formation which can have big implications for human health.

Publication: Mads Lichtenberg, et al., Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa, Cell Reports (2023). DOI:10.1016/j.celrep.2022.111515

Original Story Source: University of Copenhagen