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Machine-learning tool enhances prediction of splice-altering genetic variants

Researchers introduced Introme, a machine-learning tool that integrates multiple-splice prediction tools, additional splicing rules, and gene architecture features to evaluate the likelihood of a variant impacting splicing. The study was done by Patricia Sullivan, Velimir Gayevskiy, and several others and published by BioMed Central (BMC).

New mPROSS Algorithm Stabilizes Membrane Proteins, Enhancing Human CerS2's Stability

Researchers have developed a novel method, mPROSS, for efficiently stabilizing integral membrane proteins. This has been exemplified by successfully modifying human CerS2 for enhanced stability, leveraging AlphaFold2's structural predictions. The study, conducted by Iris D. Zelnik, Beatriz Mestre, and several others, was published on April 22, 2023.

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Ribosome profiling unveils unannotated sequences in yeast translation

A recent study has uncovered extensive translation in Saccharomyces cerevisiae, with the majority of elements, including 19,000 noncanonical ones, lacking conservation as protein-coding genes. This suggests their role in rapidly evolving genotype-phenotype connections. The research was conducted by Dr. Anne-Ruxandra Carvunis and her team at the University of Pittsburgh and published in Cell Systems.

Ingestible device reveals insights into human gut microbiome and metabolome

A study employing an ingestible device to sample the human intestinal tract during normal digestion has identified differences in microbial, proteomic, and bile acid profiles between various intestinal regions and stool. The research, conducted by Dari Shalon, Jacob Folz, among others, was published on May 10, 2023 by Nature.

Inorganic nitrogen exchange discovered to be pathway for microbial communication in marine ecosystems

A recent study has revealed that the interactions between algae and bacteria in oxygen-rich marine environments depend on the exchange of inorganic nitrogen compounds, such as nitrite and nitric oxide. These compounds act as signaling molecules, initiating a cascade that triggers algal cell death. This process could potentially contribute to the sudden collapse of oceanic algal blooms. The research was conducted by Dr. Adi Abada, Dr. Roni Beiralas, among others, and published in the ISME Journal.