In a wide-ranging paper, a UC San Diego physician-scientist explains why all chronic diseases are linked by the underlying failure of cells and the body to heal completely
UC San Diego scientists find an auto-signaling mechanism driving the T cell anti-tumor response
Study finds ambient air pollution associated with specific aspects of dementia, such as worse verbal fluency; having one version of a specific gene appears to boost and complicate the risk
Researchers identify a key player that helps prevent “insulin shock” and may lead to a therapeutic alternative to the hormone used by millions of persons with diabetes
The ubiquitous Epstein-Barr virus targets “fragile DNA,” triggering dysfunction that is associated with a variety of cancers
In both mouse and human motor neuron studies, a DNA designer drug restored levels of a protein necessary to keep motor neurons functioning, returning activity impaired in amyotrophic lateral sclerosis; findings could lead to clinical trials.
UC San Diego scientists link high levels of a gene product, abundantly produced by many types of cancer, with an elevated immune response and improved outcomes in the most common form of head and neck cancer.
In some children, pediatric acute myeloid leukemia can become resistant to treatment; UC San Diego researchers think they now know why.
In cancer stem cell and animal models, rebecsinib reversed overactive protein splicing of ADAR1 protein that drives cloning capacity and immune evasion by many malignancies.
By addressing molecules governing how host cells respond to the SARS-CoV-2 virus, researchers hope they’ve found a new therapeutic target less vulnerable to potential drug resistance and emerging variants of concern
UC San Diego researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth
UC San Diego scientists found that persons exposed to the deadly Camp Fire in 2018 displayed altered cognitive function months later; it’s new evidence of a growing phenomenon known as “climate trauma”
Brain’s characteristic wrinkled surface is generally an indicator of higher cognitive function, but too much folding can produce the opposite effect
International collaboration uncovers mosaicism, a condition in which cells within the same person have a different genetic makeup, as a cause for pediatric seizures
Tapping an almost century-long survey, UC San Diego researchers say these microscopic organisms may offer way to monitor historical marine pollution trends; and perhaps be used to predict trends in childhood and adult chronic illnesses
Inspired by the human brain, an artificial neural network was trained to spot tiny mutations in genetic sequences better and faster than human eyes
Limbic-predominant age-related TDP-43 encephalopathy (LATE) mimics Alzheimer’s, but it’s a different disease and very hard to differentiate; new findings suggest a possible clue
By directly targeting RNA, UC San Diego researchers were able to eliminate toxic protein buildup that causes the progressive neurodegenerative condition while not significantly disrupting other human genes