Researchers from the Massachusetts Institute of Technology (MIT) and the University of British Columbia have developed a groundbreaking technique called poly-transfection, which is an extension of traditional mammalian transfection. This new method involves subjecting each cell within a transfected population to a unique experiment, allowing for the analysis of numerous DNA copy numbers in a single reaction. Poly-transfection has been successful in optimizing the ratios of three-component circuits within a single cell well, with the potential for application to even larger...
Revolutionizing Real-Time MRI: Breakthrough Study Achieves Faster Scans and Sharper ImagesResearchers from Technion -- Israel Institute of Technology have made a groundbreaking discovery in the field of dynamic Magnetic Resonance Imaging (MRI).
In a recent study conducted at the University of Pittsburgh, researchers utilized advanced ribosome profiling and mass spectrometry techniques to investigate the challenges in detecting noncanonical proteins in yeast. The findings of their experiment shed light on why these proteins are often difficult to detect, providing valuable insights into the potential limitations and misleading results in estimating false discovery rates for noncanonical proteins.The study revealed that the limited detection of noncanonical proteins in yeast is primarily due to their small size and low translation levels, rather than their instability or biological insignificance.